Genetic age is a conditional notion reflecting the contribution of inherited genes to the rate of aging and potential lifespan. Unlike epigenetic clocks, which change under the influence of the environment, the DNA sequence is set at conception and hardly changes over a lifetime.
Twin studies show that heredity explains only about 20–30% of the differences in lifespan; the rest is determined by lifestyle and environment.
What is meant by genetic age
"Genetic age" has no strict clinical definition. The term is used for the contribution of inherited genes to the rate of aging and predisposition to longevity. It is not the same as epigenetic age, which largely depends on environment and lifestyle.
Nor should the notion be confused with the forensic estimation of age from DNA — there a sample is used to estimate how old a person is, not their hereditary "potential."
Heritability of lifespan
According to twin studies, genetics explains only about 20–30% of the differences in lifespan, while the remaining 70–80% is due to lifestyle and environment. Hundreds of genetic variants associated with longevity have been found, but each of them makes a very small contribution.
Genes and biomarkers of aging
Heredity partly influences the length of telomeres and the readings of epigenetic clocks. Individual genes (for example, those involved in folate metabolism, such as MTHFR) can change the body's needs. But the genotype is not a verdict: most aging processes are influenced more strongly by how a person lives.
Calculate using this marker
Calculators where Genetic age is used directly:
Frequently asked questions
Can I get a test for genetic age?
There is no single validated test. DNA genotyping shows predispositions but not an "age." The real biological age is estimated more accurately by epigenetic clocks and blood-test indices.
If I have "bad" heredity, is everything predetermined?
No. Genes account for only about 20–30% of the differences in lifespan. The main contribution comes from lifestyle, diet, activity and environment — things that can be changed.