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Phenotypic Age · Levine 2018

PhenoAge Calculator — biological age from a blood test

Phenotypic Age is the phenotypic biological age from 9 laboratory values. Enter the results of a basic blood test to get your PhenoAge, 10-year mortality risk and an estimated DNAm Age.

9biomarkers 4formulas NHANESvalidation ~3 minto fill in
Molecular markers of aging: DNA, proteins, blood cells
9
biomarkers: CBC, blood chemistry and hs-CRP — a standard panel
×1.7
increase in 10-year mortality when δPhenoAge ≥ +5 years
10 years
the Levine model's prediction horizon, validated on NHANES
4 formulas
a reproducible calculation:
xb → M → PhenoAge → DNAm Age
No lab results on hand? Estimate your biological age from body measurements in a minute — all you need is height, weight and a tape measure. Open →
Method

How PhenoAge is calculated: the Levine formula

PhenoAge was developed by Morgan Levine at Yale (2018) on NHANES-III data using Cox regression to predict mortality. The model "translates" 9 biochemical markers into years of biological age — for each additional year of PhenoAge, the risk of death rises by about 9%. If you have an extended panel on hand, the Bortz Blood Age calculator on 22 biomarkers is more accurate, and as a method among other measures, PhenoAge is examined in the review of biological age tests.

  1. 01
    xb
    Linear combination
    A weighted sum of 10 variables: 9 biomarkers and chronological age.
  2. 02
    M
    10-year risk
    A Gompertz function gives the probability of death within the next 10 years.
  3. 03
    P
    PhenoAge
    The age at which an average person in the NHANES population would have the same risk.
  4. 04
    D(P)
    DNAm Age
    An estimate of epigenetic age via a two-step transformation.

PhenoAge Calculator

Fill in 9 values and your chronological age. Sex is not part of the Levine formula and is used only to interpret the result. All fields are required.

1 Demographics
Name optional
Sex
Chronological age 18–100
years
2 Complete blood count (4 values)
MCV 80–100
fL
RDW-CV 11.5–14.5
%
WBC (white blood cells) 4.0–9.0
×10⁹/L
Lymphocytes (%) 18–40
%
3 Blood chemistry (5 values)
Albumin 35–52
g/L
Creatinine 50–110
µmol/L
Glucose 3.9–6.1
mmol/L
hs-CRP 0–5
mg/L
Alkaline phosphatase (ALP) 30–120
U/L
Phenotypic Age · Levine
—years
Your phenotypic biological age
—
Deviation from your chronological age
−15 or less −7 0 +7 +15 or more
10-year mortality risk
—%
The probability of dying within the next 10 years (the Levine model).
Estimated DNAm Age
— years
The estimated epigenetic age based on PhenoAge.
biotech Extended model · 22 biomarkers Bortz Blood Age — an estimate of the pace of aging from a full lab panel A 2023 regression model trained and validated on 306,000 UK Biobank participants. By C-index it outperforms PhenoAge by 11%. It uses an extended panel: lipids, liver enzymes, and markers of inflammation and metabolism. Open calculator
Each marker's contribution relative to the typical value
Compared with average adult values (NHANES-III). Red means the marker "ages" you relative to the typical value; green "rejuvenates." The bar length is the relative strength of the contribution.
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How to lower your biological age: personal recommendations
Below are the values that push up your PhenoAge the most, and evidence-based steps to improve them. Sorted by the size of their contribution to biological age. This is educational information, not a substitute for a doctor's consultation.
info
PhenoAge is a scientific estimate, not a clinical diagnosis. Accuracy depends on the quality of the lab data and on the units matching. The calculator uses the formulas from Levine et al. (2018), validated on NHANES. For a significant deviation from your chronological age, discuss the result with a preventive-medicine specialist.
For information only — not medical advice; consult a qualified healthcare provider before making any health decision. The values you enter are used only to calculate your result and are not stored on our servers.

Related materials

Blood Age (Bortz)
Calculator
Blood Age (Bortz)
22 biomarkers, the successor to PhenoAge — Bortz et al., 2023
Biological Age Estimate
Estimate
Biological Age Estimate
A quick estimate from height, weight, and body measurements — no labs needed

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