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Blood Age · Bortz et al. 2023

Bortz Blood Age Calculator

Bortz Blood Age is an extended biological age based on 22 blood-test markers. The model is built on 306,116 UK Biobank participants and, by C-Index, predicts mortality 11% more accurately than PhenoAge.

22biomarkers 306,116UK Biobank 0.778C-Index ~5 minto enter

Blood biomarkers: red blood cells, biochemistry, aging markers

+11%

more accurate at predicting mortality than PhenoAge (by C-Index)

biomarkers selected by an Elastic-Net Cox model from 60 candidates

306k

UK Biobank participants in the training cohort

0.778

the model's C-Index (95% CI 0.767–0.788) — on the full panel

Method

How Bortz Blood Age is calculated

Bortz Blood Age is the successor to PhenoAge, trained on a much larger cohort. Using Elastic-Net Cox regression, 25 biomarkers with the greatest predictive power were selected from 60 candidates. Each marker is compared with the UK Biobank mean, weighted by the model coefficient and summed into a biological-age acceleration. If you don't have the extended panel, a baseline estimate is given by the PhenoAge calculator from 9 blood markers, and the place of both models among other approaches is shown by the review of biological-age tests.

01

Δ

Centering

Each of the 22 biomarkers is compared with the mean value for the UK Biobank cohort.
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02

β·Δ

Weighting

The deviation is multiplied by the model coefficient β_BAA = β_ENET − β_SexAge.
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03

Σ

BAA

Contributions are summed (× 10) → biological-age acceleration: how many years “older” the blood is.
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04

BA

Biological age

Biological age = chronological age + BAA.

Bortz Blood Age Calculator

22 required markers + 4 optional (UK Biobank). Fields accept a dot or a comma as the decimal separator. Optional parameters can be left empty — the formula substitutes the mean, and their contribution will be zero.

1 Demographics

Sex

Chronological age 18–100

years

2 Complete blood count 8 markers

RBC (red blood cells) 3.8–5.7

×10¹²/L

MCH 27–33

MCV 80–100

RDW-CV 11.5–14.5

WBC (white blood cells) 4.0–9.0

×10⁹/L

Neutrophils (abs) 2.0–7.0

×10⁹/L

Monocytes (abs) 0.09–0.6

×10⁹/L

Lymphocytes (%) 18–40

These 4 parameters are produced by automated analyzers (Sysmex XE/XN), the UK Biobank standard. In most labs they are not part of a routine CBC. If you don't have them, leave them empty — the mean will be used in the formula.

MSCV ~80–95

HLR% 0.2–2.0

PDW 9–17

PCT (plateletcrit) 0.15–0.40

3 Biochemistry 13 markers

Albumin 35–52

g/L

Urea 2.5–8.3

mmol/L

Creatinine 50–110

µmol/L

Cystatin C 0.5–1.0

mg/L

Glucose 3.9–6.1

mmol/L

HbA1c 4.0–5.6

Total cholesterol 3.5–5.5

mmol/L

ApoA1 1.0–2.0

g/L

hs-CRP 0–5

mg/L

ALT ≤40 (M), ≤30 (F)

U/L

Alkaline phosphatase 30–120

U/L

GGT ≤50 (M), ≤30 (F)

U/L

Vitamin D (25(OH)D) 75–150

nmol/L

4 Hormones 1 marker

SHBG 18–54 (M), 32–128 (F)

nmol/L

Blood Age · Bortz 2023

—years

Your biological age by Bortz Blood Age

—

Deviation from your chronological age

−15 or less −7 0 +7 +15 or more

Chronological age

—

Your calendar age — the model's reference point.

Biological-age acceleration (BAA)

—

How far the blood's biology runs ahead of (or behind) your calendar age.

Contribution of each biomarker group (in years of biological age)

Positive values (red) add years to BAA. Negative ones (green) subtract.

Top 10 individual markers affecting your biological age

Comparison with UK Biobank mean values. Red means the marker “ages” you relative to the typical value, green “rejuvenates.” The bar length is the relative strength of the contribution (in years).

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How to lower your biological age: personalized recommendations

Below are the markers that push your Bortz biological age up the most, with evidence-based steps to improve them. Sorted by contribution size. This is educational information, not a substitute for a doctor's consultation.

science Baseline model · 9 markers PhenoAge — a quick estimate from 9 basic blood markers If you only have the basic panel on hand, the Morgan Levine (2018) formula gives a phenotypic biological age, a 10-year mortality risk and an estimated DNAm Age from 9 markers. Open calculator

info

Bortz Blood Age is a scientific estimate with a C-Index of 0.778, not a clinical diagnosis. The calculation uses the exact coefficients from the official R code of Bortz et al. (2023) and UK Biobank mean values for centering. If optional parameters are left empty, their contribution to BAA is zero — making the biological age slightly approximate. If the deviation is significant, discuss the result with a preventive-medicine specialist.

For information only — not medical advice; consult a qualified healthcare provider before making any health decision. The values you enter are used only to calculate your result and are not stored on our servers.

Bortz Blood Age Calculator

How Bortz Blood Age is calculated

Bortz Blood Age Calculator

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